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New Study Sheds Light on the Impact of Diabetes on Root Canal Dentin

Introduction

A recent groundbreaking study by Mohammad Ali Saghiri and colleagues has utilized high-resolution transmission electron microscopy (HRTEM) and inductively coupled plasma mass spectrometry (ICP-MS) to assess the impact of diabetes mellitus (DM) on the nanostructure of root canal dentin.

Approach

The researchers examined twenty extracted human premolars procured from both diabetic and non-diabetic patients (n=10 in each group). The teeth were decoronated and split horizontally into forty 2-mm-thick dentin discs, each assigned to a specific test. The ICP-MS method was employed to ascertain the varying elemental levels of Cu, Li, Zn, Se, Sr, Mn, and Mg in diabetic and non-diabetic specimens. HRTEM was utilized for analyzing the form and quantity of the apatite crystals in diabetic and non-diabetic dentin at the nanostructural level. The data was then subjected to statistical analysis using Kolmogorov-Smirnov and student’s t-tests (p<0.05).

Findings

The ICP-MS analysis unveiled significant variances in trace element concentrations between diabetic and non-diabetic specimens (p<0.05). Strikingly, diabetic specimens displayed lower levels of Mg, Zn, Sr, Li, Mn, and Se (p<0.05), and higher levels of Cu (p<0.05). The HRTEM analysis further revealed that diabetic dentin had a less compact structure with smaller crystallites and significantly more crystals in the 2500 nm2 area (p<0.05).

Conclusion

The study concludes that diabetic dentin showcases smaller crystallites and altered elemental levels than non-diabetic dentin. This finding could provide a potential explanation for the higher failure rate of root canal treatments in diabetic patients.

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The scientific community eagerly awaits further research in this area to fully understand the implications of these findings and to devise potential strategies for improving dental care in diabetic patients.

The study, “Effects of Diabetes on Elemental levels and Nanostructure of Root Canal Dentin,” is published in the Journal of Endodontics and available online from 8 July 2023. DOI:10.1016/j.joen.2023.07.002.

Author

  • Dr.Zainab Rangwala completed her graduation from the Goverment Dental College,Jamnagar.. Practicing since 6 years, she has a keen interest in new advances in the field of health.She is currently the head of Media and PR in Dentalreach.

Dr.Zainab Rangwala completed her graduation from the Goverment Dental College,Jamnagar.. Practicing since 6 years, she has a keen interest in new advances in the field of health.She is currently the head of Media and PR in Dentalreach.

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